3P56

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease

3P56 の概要

• エントリーDOI: 10.2210/pdb3p56/pdb
• 関連するPDBエントリー: 3KIO 3P5J
• 分子名称: Ribonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C (3 entities in total)
• 機能のキーワード: rnase h fold, triple beta-barrel, nuclease that cleaves rna/dna hybrids, proliferating cell nuclear antigen (pcna) and rna/dna hybrids, nucleus, hydrolase-replication complex, hydrolase/replication
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (Probable): O75792 Q5TBB1 Q8TDP1
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 155811.30

構造登録者

Bubeck, D.,Graham, S.C.,Jones, E.Y. (登録日: 2010-10-08, 公開日: 2010-11-17, 最終更新日: 2023-09-06)

• 主引用文献: Reijns, M.A.,Bubeck, D.,Gibson, L.C.,Graham, S.C.,Baillie, G.S.,Jones, E.Y.,Jackson, A.P.; The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease.; J.Biol.Chem., 286:10530-10539, 2011; PubMed: 21177854; DOI: 10.1074/jbc.M110.177394

実験手法

X-RAY DIFFRACTION (4.06 Å)