3P23

Crystal structure of the Human kinase and RNase domains in complex with ADP

3P23 の概要

• エントリーDOI: 10.2210/pdb3p23/pdb
• 分子名称: Serine/threonine-protein kinase/endoribonuclease IRE1, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: kinase domain, kinase and rnase function, atp binding ssrna binding, dephosphorylated, hydrolase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type I membrane protein: O75460
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 199696.02

構造登録者

Ali, M.M.U.,Pearl, L.H. (登録日: 2010-10-01, 公開日: 2011-02-23, 最終更新日: 2024-02-21)

• 主引用文献: Ali, M.M.,Bagratuni, T.,Davenport, E.L.,Nowak, P.R.,Silva-Santisteban, M.C.,Hardcastle, A.,McAndrews, C.,Rowlands, M.G.,Morgan, G.J.,Aherne, W.,Collins, I.,Davies, F.E.,Pearl, L.H.; Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.; Embo J., 30:894-905, 2011; PubMed: 21317875; DOI: 10.1038/emboj.2011.18

実験手法

X-RAY DIFFRACTION (2.7 Å)