3P0V

anti-EGFR/HER3 Fab DL11 alone

Summary for 3P0V

Entry DOI	10.2210/pdb3p0v/pdb
Related	3P0Y 3P11
Descriptor	Fab DL11 light chain, Fab DL11 heavy chain, CALCIUM ION, ... (4 entities in total)
Functional Keywords	beta-sandwich, immune system, antigens egfr and her3
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	94933.50
Authors	Eigenbrot, C.,Shia, S. (deposition date: 2010-09-29, release date: 2011-10-19, Last modification date: 2012-03-21)
Primary citation	Schaefer, G.,Haber, L.,Crocker, L.M.,Shia, S.,Shao, L.,Dowbenko, D.,Totpal, K.,Wong, A.,Lee, C.V.,Stawicki, S.,Clark, R.,Fields, C.,Lewis Phillips, G.D.,Prell, R.A.,Danilenko, D.M.,Franke, Y.,Stephan, J.P.,Hwang, J.,Wu, Y.,Bostrom, J.,Sliwkowski, M.X.,Fuh, G.,Eigenbrot, C. A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell, 20:472-486, 2011 Cited by PubMed: 22014573 DOI: 10.1016/j.ccr.2011.09.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation