3P08
Crystal structure of the human BTK kinase domain
Summary for 3P08
Entry DOI | 10.2210/pdb3p08/pdb |
Related | 3OCS 3OCT |
Descriptor | Tyrosine-protein kinase BTK (2 entities in total) |
Functional Keywords | b-cell, alpha/beta, kinase, phosphorylation, cytosol, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q06187 |
Total number of polymer chains | 2 |
Total formula weight | 62415.71 |
Authors | Yu, C.L.,Hymowitz, S.G. (deposition date: 2010-09-27, release date: 2010-11-03, Last modification date: 2023-09-06) |
Primary citation | Di Paolo, J.,Huang, T.,Balazs, M.,Barbosa, J.,Barck, K.H.,Bravo, B.,Carano, R.A.D.,Darrow, J.,Davies, D.R.,DeForge, L.E.,Diehl, L.,Ferrando, R.,Gallion, S.L.,Gianetti, A.M.,Gribling, P.,Hurez, V.,Hymowitz, S.G.,Jones, R.,Kropf, J.E.,Lee, W.P.,Maciejewski, P.M.,Mitchell, S.A.,Rong, H.,Staker, B.L.,Whitney, J.A.,Yeh, S.,Young, W.,Yu, C.,Zhang, J.,Reif, K.,Currie, K.S. A novel, specific BTK inhibitor antagonizes BCR and FcgR signaling and suppresses inflammatory arthritis To be Published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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