3OX1

X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values

Summary for 3OX1

Entry DOI	10.2210/pdb3ox1/pdb
Related	3OVM 3OWH 3OWX
Descriptor	Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	qr2, nq02, flavoprotein, metal-2 binding, oxidoreductase, phosphoprotein, fad
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P16083
Total number of polymer chains	2
Total formula weight	54275.74
Authors	Pegan, S.D.,Sturdy, M.,Ferry, G.,Delagrange, P.,Boutin, J.A.,Mesecar, A.D. (deposition date: 2010-09-21, release date: 2011-05-25, Last modification date: 2024-02-21)
Primary citation	Pegan, S.D.,Sturdy, M.,Ferry, G.,Delagrange, P.,Boutin, J.A.,Mesecar, A.D. X-ray structural studies of quinone reductase 2 nanomolar range inhibitors. Protein Sci., 20:1182-1195, 2011 Cited by PubMed: 21538647 DOI: 10.1002/pro.647 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation