Crystal structure of PPARgamma ligand binding domain in complex with tetrabromo-bisphenol A (TBBPA)

Summary for 3OSW

DescriptorPeroxisome proliferator-activated receptor gamma, 4,4'-propane-2,2-diylbis(2,6-dibromophenol), S-1,2-PROPANEDIOL, ... (4 entities in total)
Functional Keywordstranscription, ligand binding protein
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight65539.11
le Maire, A.,Bourguet, W. (deposition date: 2010-09-10, release date: 2011-05-25, Last modification date: 2019-07-17)
Primary citation
Riu, A.,Grimaldi, M.,le Maire, A.,Bey, G.,Phillips, K.,Boulahtouf, A.,Perdu, E.,Zalko, D.,Bourguet, W.,Balaguer, P.
Peroxisome proliferator-activated receptor Gamma is a target for halogenated analogs of bisphenol A.
Environ.Health Perspect., 119:1227-1232, 2011
PubMed: 21561829 (PDB entries with the same primary citation)
DOI: 10.1289/ehp.1003328
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25114 0.2% 6.5% 2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report