3OSI

Crystal structure of PPARgamma ligand binding domain in complex with tetrachloro-bisphenol A (TCBPA)

Summary for 3OSI

• Entry DOI: 10.2210/pdb3osi/pdb
• Related: 3OSW
• Descriptor: Peroxisome proliferator-activated receptor gamma, 4,4'-propane-2,2-diylbis(2,6-dichlorophenol), S-1,2-PROPANEDIOL, ... (4 entities in total)
• Functional Keywords: transcription, ligand binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65361.31

Authors

le Maire, A.,Bourguet, W. (deposition date: 2010-09-09, release date: 2011-05-25, Last modification date: 2024-02-21)

Primary citation

Riu, A.,Grimaldi, M.,le Maire, A.,Bey, G.,Phillips, K.,Boulahtouf, A.,Perdu, E.,Zalko, D.,Bourguet, W.,Balaguer, P.
Peroxisome proliferator-activated receptor Gamma is a target for halogenated analogs of bisphenol A.
Environ.Health Perspect., 119:1227-1232, 2011

PubMed Abstract: The occurrence of halogenated analogs of the xenoestrogen bisphenol A (BPA) has been recently demonstrated both in environmental and human samples. These analogs include brominated [e.g., tetrabromobisphenol A (TBBPA)] and chlorinated [e.g., tetrachlorobisphenol A (TCBPA)] bisphenols, which are both flame retardants. Because of their structural homology with BPA, such chemicals are candidate endocrine disruptors. However, their possible target(s) within the nuclear hormone receptor superfamily has remained unknown.

PubMed: 21561829
DOI: 10.1289/ehp.1003328

Experimental method

X-RAY DIFFRACTION (2.7 Å)