3OPD

Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a benzamide derivative

Summary for 3OPD

• Entry DOI: 10.2210/pdb3opd/pdb
• Related: 3O6O 3OMU
• Descriptor: Heat shock protein 83, 4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-2-[(cis-4-hydroxycyclohexyl)amino]benzamide (3 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, chaperone, atp binding
• Biological source: Trypanosoma brucei brucei
• Cellular location: Cytoplasm: P12861
• Total number of polymer chains: 3
• Total formula weight: 79994.59

Authors

Pizarro, J.C.,Wernimont, A.K.,Hutchinson, A.,Sullivan, H.,Chamberlain, K.,Weadge, J.,Cossar, D.,Li, Y.,Kozieradzki, I.,Bochkarev, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Wyatt, P.G.,Fairlamb, A.H.,MacKenzie, C.,Ferguson, M.A.J.,Hui, R.,Hills, T.,Structural Genomics Consortium (SGC) (deposition date: 2010-08-31, release date: 2010-10-13, Last modification date: 2023-09-06)

• Primary citation: Pizarro, J.C.,Hills, T.,Senisterra, G.,Wernimont, A.K.,Mackenzie, C.,Norcross, N.R.,Ferguson, M.A.,Wyatt, P.G.,Gilbert, I.H.,Hui, R.; Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.; PLoS Negl Trop Dis, 7:e2492-e2492, 2013; PubMed: 24147171; DOI: 10.1371/journal.pntd.0002492

Experimental method

X-RAY DIFFRACTION (2.6 Å)