3OMU
Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a thienopyrimidine derivative
Summary for 3OMU
Entry DOI | 10.2210/pdb3omu/pdb |
Related | 3O6O |
Descriptor | Heat shock protein 83, 2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide (3 entities in total) |
Functional Keywords | hsp90, trypanosoma bruceii, structural genomics, drug discovery, structural genomics consortium, sgc, chaperone |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 2 |
Total formula weight | 53365.62 |
Authors | Wernimont, A.K.,Hutchinson, A.,Sullivan, H.,Weadge, J.,Cossar, D.,Li, Y.,Kozieradzki, I.,Bochkarev, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Wyatt, P.G.,Fairlamb, A.H.,MacKenzie, C.,Ferguson, M.A.J.,Hui, R.,Pizarro, J.C.,Hills, T.,Structural Genomics Consortium (SGC) (deposition date: 2010-08-27, release date: 2010-10-27, Last modification date: 2023-09-06) |
Primary citation | Pizarro, J.C.,Hills, T.,Senisterra, G.,Wernimont, A.K.,Mackenzie, C.,Norcross, N.R.,Ferguson, M.A.,Wyatt, P.G.,Gilbert, I.H.,Hui, R. Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. PLoS Negl Trop Dis, 7:e2492-e2492, 2013 Cited by PubMed: 24147171DOI: 10.1371/journal.pntd.0002492 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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