3ONW

Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif.

3ONW の概要

関連するPDBエントリー2om2 1kjy
分子名称Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
機能のキーワードrgs14 goloco, rosetta, protein design, affinity enhancement, ras-like domain, all-helical domain, goloco motif, arginine finger, signaling protein, lipoprotein, transducer, guanine nucleotide dissociation inhibitor, gtp binding, nucleotide binding, adp-ribosylation
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Nucleus (By similarity) P63096 O43566
ポリマー鎖数4
分子量合計84195.11
構造登録者
Bosch, D.,Kimple, A.J.,Sammond, D.W.,Miley, M.J.,Machius, M.,Kuhlman, B.,Willard, F.S.,Siderovski, D.P. (登録日: 2010-08-30, 公開日: 2010-11-24, 最終更新日: 2011-07-13)
主引用文献
Bosch, D.E.,Kimple, A.J.,Sammond, D.W.,Muller, R.E.,Miley, M.J.,Machius, M.,Kuhlman, B.,Willard, F.S.,Siderovski, D.P.
Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286:3351-3358, 2011
PubMed: 21115486 (主引用文献が同じPDBエントリー)
DOI: 10.1074/jbc.M110.190496
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.38 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25520.1%2.3%14.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード