3ONI

Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor JQ1

Summary for 3ONI

Entry DOI	10.2210/pdb3oni/pdb
Descriptor	Bromodomain containing 2, isoform CRA_a, (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, NICKEL (II) ION, ... (5 entities in total)
Functional Keywords	structural genomics, structural genomics consortium, sgc, bromodomain, inhibition, probe, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	14074.93
Authors	Filippakopoulos, P.,Picaud, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Bradner, J.E.,Structural Genomics Consortium (SGC) (deposition date: 2010-08-29, release date: 2010-10-06, Last modification date: 2023-09-06)
Primary citation	Filippakopoulos, P.,Qi, J.,Picaud, S.,Shen, Y.,Smith, W.B.,Fedorov, O.,Morse, E.M.,Keates, T.,Hickman, T.T.,Felletar, I.,Philpott, M.,Munro, S.,McKeown, M.R.,Wang, Y.,Christie, A.L.,West, N.,Cameron, M.J.,Schwartz, B.,Heightman, T.D.,La Thangue, N.,French, C.A.,Wiest, O.,Kung, A.L.,Knapp, S.,Bradner, J.E. Selective inhibition of BET bromodomains. Nature, 468:1067-1073, 2010 Cited by PubMed: 20871596 DOI: 10.1038/nature09504 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation