Summary for 3OMV
Entry DOI | 10.2210/pdb3omv/pdb |
Related | 3D4Q |
Descriptor | RAF proto-oncogene serine/threonine-protein kinase, (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime (2 entities in total) |
Functional Keywords | serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): P04049 |
Total number of polymer chains | 2 |
Total formula weight | 71608.36 |
Authors | Hatzivassiliou, G.,Song, K.,Yen, I.,Brandhuber, B.J.,Anderson, D.J.,Alvarado, R.,Ludlam, M.J.,Stokoe, D.,Gloor, S.L.,Vigers, G.P.A.,Morales, T.,Aliagas, I.,Liu, B.,Sideris, S.,Hoeflich, K.P.,Jaiswal, B.S.,Seshagiri, S.,Koeppen, H.,Belvin, M.,Friedman, L.S.,Malek, S. (deposition date: 2010-08-27, release date: 2010-09-15, Last modification date: 2023-09-06) |
Primary citation | Hatzivassiliou, G.,Song, K.,Yen, I.,Brandhuber, B.J.,Anderson, D.J.,Alvarado, R.,Ludlam, M.J.,Stokoe, D.,Gloor, S.L.,Vigers, G.,Morales, T.,Aliagas, I.,Liu, B.,Sideris, S.,Hoeflich, K.P.,Jaiswal, B.S.,Seshagiri, S.,Koeppen, H.,Belvin, M.,Friedman, L.S.,Malek, S. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature, 464:431-435, 2010 Cited by PubMed: 20130576DOI: 10.1038/nature08833 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4 Å) |
Structure validation
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