3OMV

Crystal structure of c-raf (raf-1)

Replaces:  3LB7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	RAF proto-oncogene serine/threonine-protein kinase	polymer	307	35430.7	2	UniProt (P04049) Pfam (PF07714)	Homo sapiens (human)	Proto-oncogene c-RAF, cRaf, Raf-1
2	C, D (A, B)	(1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime	non-polymer		373.5	2	Chemie (SM5)

Sequence modifications

A, B: 323 - 618 (UniProt: P04049)

PDB	External Database	Details
Met 312	-	expression tag
Asp 313	-	expression tag
Arg 314	-	expression tag
Gly 315	-	expression tag
Ser 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70861.5
Non-Polymers*	Number of molecules	2
	Total formula weight	746.9
All*	Total formula weight	71608.4

*Water molecules are not included.