3OMJ

Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding

Summary for 3OMJ

• Entry DOI: 10.2210/pdb3omj/pdb
• Descriptor: 5'-D(*CP*(C38)P*AP*GP*TP*AP*CP*TP*GP*G)-3', CALCIUM ION, (23R,52R)-23,52-diamino-5,11,17,28,34,40,46,57-octamethyl-2,5,8,11,14,17,20,25,28,31,34,37,40,43,46,49,54,57,60,64-icosaazanonacyclo[54.2.1.1~4,7~.1~10,13~.1~16,19~.1~27,30~.1~33,36~.1~39,42~.1~45,48~]hexahexaconta-1(58),4(66),6,10(65),12,16(64),18,27(63),29,33(62),35,39(61),41,45(60),47,56(59)-hexadecaene-3,9,15,21,26,32,38,44,50,55-decone, ... (4 entities in total)
• Functional Keywords: cyclic py-im polyamide, dna
• Total number of polymer chains: 2
• Total formula weight: 7681.33

Authors

Chenoweth, D.M. (deposition date: 2010-08-27, release date: 2010-09-08, Last modification date: 2024-02-21)

• Primary citation: Chenoweth, D.M.,Dervan, P.B.; Structural basis for cyclic py-im polyamide allosteric inhibition of nuclear receptor binding.; J.Am.Chem.Soc., 132:14521-14529, 2010; PubMed: 20812704; DOI: 10.1021/ja105068b

Experimental method

X-RAY DIFFRACTION (0.95 Å)