3OJ2

Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation

3OJ2 の概要

• エントリーDOI: 10.2210/pdb3oj2/pdb
• 関連するPDBエントリー: 1DJS 1EVT 1RY7 3OJM 3OJV
• 分子名称: Heparin-binding growth factor 1, Fibroblast growth factor receptor 2, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: beta trefoil motif, immunoglobulin-like domain, growth factor, growth factor receptor, extracellular, cytokine-signaling protein complex, cytokine/signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P05230; Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 87400.40

構造登録者

Beenken, A.,Mohammadi, M. (登録日: 2010-08-20, 公開日: 2011-08-31, 最終更新日: 2023-09-06)

• 主引用文献: Beenken, A.,Eliseenkova, A.V.,Ibrahimi, O.A.,Olsen, S.K.,Mohammadi, M.; Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.; J.Biol.Chem., 287:3067-3078, 2012; PubMed: 22057274; DOI: 10.1074/jbc.M111.275891

実験手法

X-RAY DIFFRACTION (2.2 Å)