3OFI

Crystal structure of human insulin-degrading enzyme in complex with ubiquitin

Summary for 3OFI

• Entry DOI: 10.2210/pdb3ofi/pdb
• Descriptor: Insulin-degrading enzyme, Ubiquitin, ZINC ION, ... (5 entities in total)
• Functional Keywords: protein-peptide complex, hydrolase, human insulin-degrading enzyme, ubiquitin, exosite
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P14735; Ubiquitin: Cytoplasm : P0CG48
• Total number of polymer chains: 4
• Total formula weight: 246669.95

Authors

Kalas, V.,Ralat, L.A.,Tang, W.-J. (deposition date: 2010-08-15, release date: 2010-09-08, Last modification date: 2023-09-06)

• Primary citation: Ralat, L.A.,Kalas, V.,Zheng, Z.,Goldman, R.D.,Sosnick, T.R.,Tang, W.J.; Ubiquitin is a novel substrate for human insulin-degrading enzyme.; J.Mol.Biol., 406:454-466, 2011; PubMed: 21185309; DOI: 10.1016/j.jmb.2010.12.026

Experimental method

X-RAY DIFFRACTION (2.35 Å)