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3OB1

Crystal structure of c-Cbl TKB domain in complex with double phosphorylated Spry2 peptide

Summary for 3OB1
Entry DOI10.2210/pdb3ob1/pdb
Related3OB2
Descriptor12-meric peptide from Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL (3 entities in total)
Functional Keywordsprotein-peptide complex, double phosphorylation, complex, e3 ubiquitin ligase, spry2, phosphorylation, ligase-signaling protein complex, ligase/signaling protein
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm, cytoskeleton : O43597
Cytoplasm: P22681
Total number of polymer chains2
Total formula weight39747.50
Authors
Sun, Q.,Sivaraman, J. (deposition date: 2010-08-06, release date: 2010-08-18, Last modification date: 2023-12-06)
Primary citationSun, Q.,Jackson, R.A.,Ng, C.,Guy, G.R.,Sivaraman, J.
Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5:e12819-e12819, 2010
Cited by
PubMed: 20877636
DOI: 10.1371/journal.pone.0012819
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

数据于2024-03-27公开中

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