3O95
Crystal Structure of Human DPP4 Bound to TAK-100
Summary for 3O95
Entry DOI | 10.2210/pdb3o95/pdb |
Related | 3O9V |
Related PRD ID | PRD_900017 |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | protease and 8-bladed beta-propeller domain, aminopeptidase, cell membrane, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 350774.62 |
Authors | Yano, J.K.,Aertgeerts, K. (deposition date: 2010-08-03, release date: 2011-01-26, Last modification date: 2020-07-29) |
Primary citation | Miyamoto, Y.,Banno, Y.,Yamashita, T.,Fujimoto, T.,Oi, S.,Moritoh, Y.,Asakawa, T.,Kataoka, O.,Yashiro, H.,Takeuchi, K.,Suzuki, N.,Ikedo, K.,Kosaka, T.,Tsubotani, S.,Tani, A.,Sasaki, M.,Funami, M.,Amano, M.,Yamamoto, Y.,Aertgeerts, K.,Yano, J.,Maezaki, H. Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor. J.Med.Chem., 53:3517-3531, 2011 Cited by PubMed: 21218817DOI: 10.1021/jm101236h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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