3O95
Crystal Structure of Human DPP4 Bound to TAK-100
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Dipeptidyl peptidase 4 | polymer | 740 | 85775.9 | 4 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) In PDB | Homo sapiens (human) | Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Adenosine deaminase complexing protein 2, ADCP-2, ADABP |
2 | E, F, G, H, I... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
3 | K | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 1 | In PDB BIRD (PRD_900017) GlyTouCan (G47362BJ) | triacetyl-beta-chitotriose | ||
4 | D, A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) | |||
5 | D, A, B, C | [5-(aminomethyl)-6-(2,2-dimethylpropyl)-2-ethyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid | non-polymer | 354.5 | 4 | Chemie (01T) | |||
6 | water | water | 18.0 | 487 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 39 - 766 (UniProt: P27487)
PDB | External Database | Details |
---|---|---|
Ala 27 | - | expression tag |
Asp 28 | - | expression tag |
Pro 29 | - | expression tag |
Gly 30 | - | expression tag |
Gly 31 | - | expression tag |
Ser 32 | - | expression tag |
His 33 | - | expression tag |
His 34 | - | expression tag |
His 35 | - | expression tag |
His 36 | - | expression tag |
His 37 | - | expression tag |
His 38 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 343103.8 | |
Branched | Number of molecules | 8 |
Total formula weight | 3598.4 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 4072.4 | |
All* | Total formula weight | 350774.6 |