3O7U

Crystal structure of Cytosine Deaminase from Escherichia Coli complexed with zinc and phosphono-cytosine

Summary for 3O7U

• Entry DOI: 10.2210/pdb3o7u/pdb
• Related: 1K6W
• Descriptor: Cytosine deaminase, (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, ZINC ION, ... (7 entities in total)
• Functional Keywords: (beta-alpha)8 barrel, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 49055.94

Authors

Fedorov, A.A.,Fedorov, E.V.,Hall, R.S.,Raushel, F.M.,Almo, S.C. (deposition date: 2010-07-31, release date: 2011-06-15, Last modification date: 2023-10-04)

• Primary citation: Hall, R.S.,Fedorov, A.A.,Xu, C.,Fedorov, E.V.,Almo, S.C.,Raushel, F.M.; Three-dimensional structure and catalytic mechanism of Cytosine deaminase.; Biochemistry, 50:5077-5085, 2011; PubMed: 21545144; DOI: 10.1021/bi200483k

Experimental method

X-RAY DIFFRACTION (1.708 Å)