Crystal structure of Cytosine Deaminase from Escherichia Coli complexed with zinc and phosphono-cytosine

Summary for 3O7U

DescriptorCytosine deaminase, (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, ZINC ION, ... (7 entities in total)
Functional Keywords(beta-alpha)8 barrel, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceEscherichia coli
Total number of polymer chains1
Total molecular weight49055.94
Fedorov, A.A.,Fedorov, E.V.,Hall, R.S.,Raushel, F.M.,Almo, S.C. (deposition date: 2010-07-31, release date: 2011-06-15, Last modification date: 2012-03-07)
Primary citation
Hall, R.S.,Fedorov, A.A.,Xu, C.,Fedorov, E.V.,Almo, S.C.,Raushel, F.M.
Three-dimensional structure and catalytic mechanism of Cytosine deaminase.
Biochemistry, 50:5077-5085, 2011
PubMed: 21545144 (PDB entries with the same primary citation)
DOI: 10.1021/bi200483k
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.189300.6%5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report