3O5N
Tetrahydroquinoline carboxylates are potent inhibitors of the Shank PDZ domain, a putative target in autism disorders
Summary for 3O5N
Entry DOI | 10.2210/pdb3o5n/pdb |
Descriptor | SH3 and multiple ankyrin repeat domains protein 3, (3aS,4R,9bR)-9-nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4,6-dicarboxylic acid (3 entities in total) |
Functional Keywords | pdz domain, protein-protein interaction, gkap, postsynaptic density, protein binding |
Biological source | Mus musculus (mouse) |
Cellular location | Cytoplasm: Q4ACU6 |
Total number of polymer chains | 8 |
Total formula weight | 97951.67 |
Authors | Saupe, J.,Roske, Y.,Schillinger, C.,Kamdem, N.,Radetzki, S.,Diehl, A.,Oschkinat, H.,Krause, G.,Heinemann, U.,Rademann, J. (deposition date: 2010-07-28, release date: 2011-06-15, Last modification date: 2024-02-21) |
Primary citation | Saupe, J.,Roske, Y.,Schillinger, C.,Kamdem, N.,Radetzki, S.,Diehl, A.,Oschkinat, H.,Krause, G.,Heinemann, U.,Rademann, J. Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the shank3 PDZ domain. Chemmedchem, 6:1411-1422, 2011 Cited by PubMed: 21626699DOI: 10.1002/cmdc.201100094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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