3O5N
Tetrahydroquinoline carboxylates are potent inhibitors of the Shank PDZ domain, a putative target in autism disorders
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE BR0 E 1 |
| Chain | Residue |
| B | ASP652 |
| E | ARG725 |
| E | GLY655 |
| E | PHE656 |
| E | GLY657 |
| E | PHE658 |
| E | VAL659 |
| E | LEU660 |
| E | VAL721 |
| E | ILE724 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| B | TRP694 | |
| C | TRP694 | |
| D | TRP694 | |
| E | TRP694 | |
| F | TRP694 | |
| G | TRP694 | |
| H | TRP694 | |
| A | TRP694 |
