3O0J

PDE4B In complex with ligand an2898

Summary for 3O0J

• Entry DOI: 10.2210/pdb3o0j/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: phosphodiesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 38548.01

Authors

Alley, M.R.K.,Zhou, Y. (deposition date: 2010-07-19, release date: 2011-08-10, Last modification date: 2024-02-21)

• Primary citation: Freund, Y.R.,Akama, T.,Alley, M.R.,Antunes, J.,Dong, C.,Jarnagin, K.,Kimura, R.,Nieman, J.A.,Maples, K.R.,Plattner, J.J.,Rock, F.,Sharma, R.,Singh, R.,Sanders, V.,Zhou, Y.; Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.; Febs Lett., 586:3410-3414, 2012; PubMed: 22841723; DOI: 10.1016/j.febslet.2012.07.058

Experimental method

X-RAY DIFFRACTION (1.95 Å)