3NZJ

Crystal structure of yeast 20S proteasome in complex with ligand 2a

Summary for 3NZJ

• Entry DOI: 10.2210/pdb3nzj/pdb
• Related: 1JD2 1RYP 3NZW 3NZX
• Related PRD ID: PRD_001103
• Descriptor: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (17 entities in total)
• Functional Keywords: ubiquitin, protein degradation, n-terminal nucleophilic hydrolase, 19s regulatory particle, ubiquitin-tagged substrates, cytosol, nucleus, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 30
• Total formula weight: 768666.31

Authors

Groll, M.,Gallastegui, N.,Marechal, X.,Le Ravalec, V.,Basse, N.,Richy, N.,Genin, E.,Huber, R.,Moroder, M.,Vidal, V.,Reboud-Ravaux, M. (deposition date: 2010-07-16, release date: 2011-02-16, Last modification date: 2023-11-22)

• Primary citation: Groll, M.,Gallastegui, N.,Marechal, X.,Le Ravalec, V.,Basse, N.,Richy, N.,Genin, E.,Huber, R.,Moroder, L.,Vidal, J.,Reboud-Ravaux, M.; 20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.; Chemmedchem, 5:1701-1705, 2010; PubMed: 20715286; DOI: 10.1002/cmdc.201000293

Experimental method

X-RAY DIFFRACTION (2.4 Å)