3NZI
Substrate induced remodeling of the active site regulates HtrA1 activity
Summary for 3NZI
Entry DOI | 10.2210/pdb3nzi/pdb |
Related | 3NUM 3NWU |
Descriptor | Serine protease HTRA1, Citrate synthase (2 entities in total) |
Functional Keywords | serine protease, degp, htra, protease, hydrolase-peptide inhibitor complex, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane : Q92743 |
Total number of polymer chains | 2 |
Total formula weight | 37535.77 |
Authors | Truebestein, L.,Tennstaedt, A.,Hauske, P.,Krojer, T.,Kaiser, M.,Clausen, T.,Ehrmann, M. (deposition date: 2010-07-16, release date: 2011-02-23, Last modification date: 2023-11-22) |
Primary citation | Truebestein, L.,Tennstaedt, A.,Monig, T.,Krojer, T.,Canellas, F.,Kaiser, M.,Clausen, T.,Ehrmann, M. Substrate-induced remodeling of the active site regulates human HTRA1 activity. Nat.Struct.Mol.Biol., 18:386-388, 2011 Cited by PubMed: 21297635DOI: 10.1038/nsmb.2013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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