3NZB

Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of Potent 5-(omega-carboxyl(alkyloxy)pyrido[2,-d]pyrimidine Derivatives

3NZB の概要

• エントリーDOI: 10.2210/pdb3nzb/pdb
• 関連するPDBエントリー: 2fzh 2fzi 2fzj 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZ6 3NZ9 3NZA 3NZC 3NZD
• 分子名称: Dihydrofolate reductase, ethyl 6-{3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy}hexanoate, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: pneumocystius carinii dhfr inhibitor complexes, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25571.03

構造登録者

Cody, V. (登録日: 2010-07-16, 公開日: 2010-12-29, 最終更新日: 2023-09-06)

• 主引用文献: Cody, V.,Pace, J.; Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-([omega]-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives; Acta Crystallogr.,Sect.D, 67:1-7, 2011; PubMed: 21206056; DOI: 10.1107/S0907444910041004

実験手法

X-RAY DIFFRACTION (1.45 Å)