Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0004146 | molecular_function | dihydrofolate reductase activity |
| X | 0005739 | cellular_component | mitochondrion |
| X | 0006730 | biological_process | one-carbon metabolic process |
| X | 0016491 | molecular_function | oxidoreductase activity |
| X | 0046452 | biological_process | dihydrofolate metabolic process |
| X | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| X | 0046655 | biological_process | folic acid metabolic process |
| X | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE D2N X 207 |
| Chain | Residue |
| X | ILE10 |
| X | TYR129 |
| X | NDP208 |
| X | HOH266 |
| X | VAL11 |
| X | ALA12 |
| X | SER24 |
| X | LEU25 |
| X | GLU32 |
| X | PHE36 |
| X | PRO66 |
| X | ILE123 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NDP X 208 |
| Chain | Residue |
| X | VAL11 |
| X | ALA12 |
| X | ILE19 |
| X | GLY20 |
| X | SER24 |
| X | LEU25 |
| X | TRP27 |
| X | GLY58 |
| X | ARG59 |
| X | LYS60 |
| X | THR61 |
| X | SER64 |
| X | ILE80 |
| X | THR81 |
| X | ARG82 |
| X | LYS96 |
| X | ILE123 |
| X | GLY124 |
| X | GLY125 |
| X | ALA126 |
| X | GLN127 |
| X | LEU128 |
| X | TYR129 |
| X | ALA131 |
| X | D2N207 |
| X | D2N209 |
| X | HOH232 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE D2N X 209 |
| Chain | Residue |
| X | ILE10 |
| X | VAL11 |
| X | ALA12 |
| X | GLU32 |
| X | ILE33 |
| X | PHE36 |
| X | LYS37 |
| X | PRO66 |
| X | PHE69 |
| X | LYS73 |
| X | ILE123 |
| X | TYR129 |
| X | NDP208 |
| X | HOH219 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGrsnsLPWklkk.EisyFkrvT |
| Chain | Residue | Details |
| X | GLY18-THR40 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| X | ALA12 | |
| X | GLY18 | |
| X | ARG59 | |
| X | THR81 | |
| X | GLY124 | |
| Chain | Residue | Details |
| X | GLU32 | |
| X | ARG75 | |
