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2FZH

New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives

Summary for 2FZH
Entry DOI10.2210/pdb2fzh/pdb
Related1U7O 2CD2 2FZI 2FZJ
DescriptorDihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE, ... (4 entities in total)
Functional Keywordsdihydrofolate reductase, trimethoprim derivatives, ring stacking interactions, oxidoreductase
Biological sourcePneumocystis carinii
Total number of polymer chains1
Total formula weight25010.34
Authors
Cody, V.,Pace, J.,Chisum, K.,Rosowsky, A. (deposition date: 2006-02-09, release date: 2006-12-26, Last modification date: 2023-08-30)
Primary citationCody, V.,Pace, J.,Chisum, K.,Rosowsky, A.
New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.
Proteins, 65:959-969, 2006
Cited by
PubMed: 17019704
DOI: 10.1002/prot.21131
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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