3NY6

Catalytic fragment of cholix toxin from vibrio cholerae in complex with inhibitor V30

Summary for 3NY6

• Entry DOI: 10.2210/pdb3ny6/pdb
• Related: 2Q6M 3ESS 3KI0 3KI1 3KI2 3KI3 3KI4 3KI5 3KI6 3KI7
• Descriptor: Cholix toxin, GLYCEROL, 2-[(5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-(2-hydroxyethyl)acetamide, ... (5 entities in total)
• Functional Keywords: alpha-beta complex, adp-ribosyl transferase, nad+ binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Vibrio cholerae
• Total number of polymer chains: 1
• Total formula weight: 23927.40

Authors

Merrill, A.R.,Jorgensen, R. (deposition date: 2010-07-14, release date: 2010-12-29, Last modification date: 2023-09-06)

• Primary citation: Turgeon, Z.,Jorgensen, R.,Visschedyk, D.,Edwards, P.R.,Legree, S.,McGregor, C.,Fieldhouse, R.J.,Mangroo, D.,Schapira, M.,Merrill, A.R.; Newly discovered and characterized antivirulence compounds inhibit bacterial mono-ADP-ribosyltransferase toxins.; Antimicrob.Agents Chemother., 55:983-991, 2011; PubMed: 21135177; DOI: 10.1128/AAC.01164-10

Experimental method

X-RAY DIFFRACTION (1.68 Å)