Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3NW7

Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (34)

Summary for 3NW7
Entry DOI10.2210/pdb3nw7/pdb
Related3NW5 3NW6
DescriptorInsulin-like growth factor 1 receptor, N-({4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamide (3 entities in total)
Functional Keywordshormone/growth factor, igf-1r, kinase domain, transferase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P08069
Total number of polymer chains1
Total formula weight35433.62
Authors
Sack, J.S. (deposition date: 2010-07-09, release date: 2010-07-28, Last modification date: 2024-02-21)
Primary citationSampognaro, A.J.,Wittman, M.D.,Carboni, J.M.,Chang, C.,Greer, A.F.,Hurlburt, W.W.,Sack, J.S.,Vyas, D.M.
Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.
Bioorg.Med.Chem.Lett., 20:5027-5030, 2010
Cited by
PubMed: 20675137
DOI: 10.1016/j.bmcl.2010.07.045
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.11 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon