3NW7
Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (34)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-like growth factor 1 receptor | polymer | 307 | 35041.2 | 1 | UniProt (P08069) Pfam (PF07714) | Homo sapiens (human) | Insulin-like growth factor I receptor, IGF-I receptor |
| 2 | B (A) | N-({4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamide | non-polymer | 392.4 | 1 | Chemie (LGV) | |||
| 3 | C (A) | water | water | 18.0 | 289 | Chemie (HOH) |
Sequence modifications
A: 952 - 1256 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| Met 950 | - | expression tag |
| Val 951 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35041.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 392.4 | |
| All* | Total formula weight | 35433.6 |
