3NW2

Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights

Summary for 3NW2

Entry DOI	10.2210/pdb3nw2/pdb
Related	1NOD
Descriptor	Nitric oxide synthase, inducible, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywords	calmodulin-binding, fad, fmn, iron, metal-binding, nadp, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	2
Total formula weight	100317.49
Authors	Graedler, U.,Fuchss, T.,Ulrich, W.R.,Boer, R.,Strub, A.,Hesslinger, C.,Anezo, C.,Diederichs, K.,Zaliani, A. (deposition date: 2010-07-09, release date: 2011-06-22, Last modification date: 2023-11-01)
Primary citation	Graedler, U.,Fuchss, T.,Ulrich, W.R.,Boer, R.,Strub, A.,Hesslinger, C.,Anezo, C.,Diederichs, K.,Zaliani, A. Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights Bioorg.Med.Chem.Lett., 21:4228-4232, 2011 Cited by PubMed: 21684157 DOI: 10.1016/j.bmcl.2011.05.073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation