3NW2
Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights
Summary for 3NW2
| Entry DOI | 10.2210/pdb3nw2/pdb |
| Related | 1NOD |
| Descriptor | Nitric oxide synthase, inducible, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total) |
| Functional Keywords | calmodulin-binding, fad, fmn, iron, metal-binding, nadp, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Mus musculus (mouse) |
| Total number of polymer chains | 2 |
| Total formula weight | 100317.49 |
| Authors | Graedler, U.,Fuchss, T.,Ulrich, W.R.,Boer, R.,Strub, A.,Hesslinger, C.,Anezo, C.,Diederichs, K.,Zaliani, A. (deposition date: 2010-07-09, release date: 2011-06-22, Last modification date: 2024-10-30) |
| Primary citation | Graedler, U.,Fuchss, T.,Ulrich, W.R.,Boer, R.,Strub, A.,Hesslinger, C.,Anezo, C.,Diederichs, K.,Zaliani, A. Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights Bioorg.Med.Chem.Lett., 21:4228-4232, 2011 Cited by PubMed Abstract: Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause stroke or septic shock. Several classes of potent NOS inhibitors have been reported, most of them targeting the arginine binding site of the oxygenase domain. Here we disclose the SAR and the rational design of potent and selective iNOS inhibitors which may be useful as anti-inflammatory drugs. PubMed: 21684157DOI: 10.1016/j.bmcl.2011.05.073 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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