3NW2
Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nitric oxide synthase, inducible | polymer | 423 | 48998.7 | 2 | UniProt (P29477) Pfam (PF02898) | Mus musculus (mouse) | Inducible NO synthase, Inducible NOS, iNOS, NOS type II, Macrophage NOS, MAC-NOS |
| 2 | C, G (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, H (A, B) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
| 4 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | F, I (A, B) | 2-[2-(4-methoxypyridin-2-yl)ethyl]-3H-imidazo[4,5-b]pyridine | non-polymer | 254.3 | 2 | Chemie (MPW) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 97997.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2320.1 | |
| All* | Total formula weight | 100317.5 |
