3NTG
Crystal structure of COX-2 with selective compound 23d-(R)
Summary for 3NTG
Entry DOI | 10.2210/pdb3ntg/pdb |
Related | 1PXX 3LN0 3LN1 3MQE 3PGH |
Descriptor | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total) |
Functional Keywords | cox2, cox-2, pgh2s-2, cyclooxygenase-2, dioxygenase, disulfide bond, endoplasmic reticulum, fatty acid biosynthesis, glycoprotein, heme, iron, lipid synthesis, membrane, metal-binding, microsome, oxidoreductase, peroxidase, phosphoprotein, prostaglandin biosynthesis |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 4 |
Total formula weight | 261163.46 |
Authors | Wang, J.L.,Limburg, D.,Graneto, M.J.,Carter, J.C.,Talley, J.J.,Kiefer, J.R. (deposition date: 2010-07-04, release date: 2010-10-27, Last modification date: 2023-12-27) |
Primary citation | Wang, J.L.,Limburg, D.,Graneto, M.J.,Springer, J.,Hamper, J.R.,Liao, S.,Pawlitz, J.L.,Kurumbail, R.G.,Maziasz, T.,Talley, J.J.,Kiefer, J.R.,Carter, J. The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life. Bioorg.Med.Chem.Lett., 20:7159-7163, 2010 Cited by PubMed: 20709553DOI: 10.1016/j.bmcl.2010.07.054 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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