3NTB
Structure of 6-methylthio naproxen analog bound to mCOX-2.
Summary for 3NTB
Entry DOI | 10.2210/pdb3ntb/pdb |
Related | 1CQE 1PXX 3NT1 3PGH |
Related PRD ID | PRD_900017 |
Descriptor | Prostaglandin-endoperoxide synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total) |
Functional Keywords | prostaglandin h2 synthase, cyclooxygeanse-2, naproxen analog, oxidoreductase |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 4 |
Total formula weight | 278816.35 |
Authors | Duggan, K.C.,Musee, J.,Walters, M.J.,Harp, J.M.,Kiefer, J.R.,Oates, J.A.,Marnett, L.J. (deposition date: 2010-07-03, release date: 2010-09-01, Last modification date: 2023-12-27) |
Primary citation | Duggan, K.C.,Walters, M.J.,Musee, J.,Harp, J.M.,Kiefer, J.R.,Oates, J.A.,Marnett, L.J. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J.Biol.Chem., 285:34950-34959, 2010 Cited by PubMed: 20810665DOI: 10.1074/jbc.M110.162982 PDB entries with the same primary citation |
Experimental method |
Structure validation
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