3NTB

Structure of 6-methylthio naproxen analog bound to mCOX-2.

Summary for 3NTB

Entry DOI	10.2210/pdb3ntb/pdb
Related	1CQE 1PXX 3NT1 3PGH
Related PRD ID	PRD_900017
Descriptor	Prostaglandin-endoperoxide synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
Functional Keywords	prostaglandin h2 synthase, cyclooxygeanse-2, naproxen analog, oxidoreductase
Biological source	Mus musculus (mouse)
Total number of polymer chains	4
Total formula weight	278816.35
Authors	Duggan, K.C.,Musee, J.,Walters, M.J.,Harp, J.M.,Kiefer, J.R.,Oates, J.A.,Marnett, L.J. (deposition date: 2010-07-03, release date: 2010-09-01, Last modification date: 2023-12-27)
Primary citation	Duggan, K.C.,Walters, M.J.,Musee, J.,Harp, J.M.,Kiefer, J.R.,Oates, J.A.,Marnett, L.J. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J.Biol.Chem., 285:34950-34959, 2010 Cited by PubMed: 20810665 DOI: 10.1074/jbc.M110.162982 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation