3NQC

Crystal structure of the mutant I96S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Summary for 3NQC

Entry DOI	10.2210/pdb3nqc/pdb
Related	3G18 3NQ6 3NQ7 3NQA 3NQD 3NQE 3NQF 3NQG 3NQM
Descriptor	Orotidine 5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE (3 entities in total)
Functional Keywords	orotidine 5'-monophosphate decarboxylase, methanobacterium thermoautotrophicum, inhibitor bmp, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Methanothermobacter thermautotrophicus
Total number of polymer chains	2
Total formula weight	50397.60
Authors	Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (deposition date: 2010-06-29, release date: 2011-05-11, Last modification date: 2024-03-20)
Primary citation	Iiams, V.,Desai, B.J.,Fedorov, A.A.,Fedorov, E.V.,Almo, S.C.,Gerlt, J.A. Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site. Biochemistry, 50:8497-8507, 2011 Cited by PubMed: 21870810 DOI: 10.1021/bi2012355 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.531 Å)

Structure validation