3NLB
Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death
Summary for 3NLB
Entry DOI | 10.2210/pdb3nlb/pdb |
Related | 2C3J 2C3K 2CGU 2CGV 2CGW 2CGX |
Descriptor | Serine/threonine-protein kinase Chk1, 3-methyl-5-[5-(1-methylethyl)-1H-benzimidazol-2-yl]-N-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide (3 entities in total) |
Functional Keywords | kinase domain, checkpoint kinase, atp binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 34528.64 |
Authors | Massey, A.J.,Borgognoni, J.,Bentley, C.,Foloppe, N.,Fiumana, A.,Walmsley, L. (deposition date: 2010-06-21, release date: 2011-05-18, Last modification date: 2024-03-20) |
Primary citation | Massey, A.J.,Borgognoni, J.,Bentley, C.,Foloppe, N.,Fiumana, A.,Walmsley, L. Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor Plos One, 5:e13123-e13123, 2010 Cited by PubMed: 20976184DOI: 10.1371/journal.pone.0013123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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