3NLB

Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death

3NLB の概要

• エントリーDOI: 10.2210/pdb3nlb/pdb
• 関連するPDBエントリー: 2C3J 2C3K 2CGU 2CGV 2CGW 2CGX
• 分子名称: Serine/threonine-protein kinase Chk1, 3-methyl-5-[5-(1-methylethyl)-1H-benzimidazol-2-yl]-N-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide (3 entities in total)
• 機能のキーワード: kinase domain, checkpoint kinase, atp binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O14757
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34528.64

構造登録者

Massey, A.J.,Borgognoni, J.,Bentley, C.,Foloppe, N.,Fiumana, A.,Walmsley, L. (登録日: 2010-06-21, 公開日: 2011-05-18, 最終更新日: 2024-03-20)

主引用文献

Massey, A.J.,Borgognoni, J.,Bentley, C.,Foloppe, N.,Fiumana, A.,Walmsley, L.
Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor
Plos One, 5:e13123-e13123, 2010

PubMed Abstract: Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between these two checkpoints.

PubMed: 20976184
DOI: 10.1371/journal.pone.0013123

実験手法

X-RAY DIFFRACTION (1.9 Å)