3NL0

Mutant P44S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase

Summary for 3NL0

• Entry DOI: 10.2210/pdb3nl0/pdb
• Related: 1WNE 1u09 2E9R 2E9T 2E9Z 2EC0 3NKY
• Descriptor: 3D polymerase, 5'-R(P*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*G*GP*GP*CP*CP*C)-3', ... (5 entities in total)
• Functional Keywords: foot-and-mouth disease virus picornavirus, 3d polymerase, rna dependent rna polymerase, transferase-rna complex, transferase/rna
• Biological source: Foot-and-mouth disease virus - type C; More
• Total number of polymer chains: 3
• Total formula weight: 57429.61

Authors

Agudo, R.,Ferrer-Orta, C.,Arias, A.,Perez-Luque, R.,Verdaguer, N.,Domingo, E. (deposition date: 2010-06-21, release date: 2011-07-13, Last modification date: 2023-11-01)

• Primary citation: Agudo, R.,Ferrer-Orta, C.,Arias, A.,de la Higuera, I.,Perales, C.,Perez-Luque, R.,Verdaguer, N.,Domingo, E.; A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.; Plos Pathog., 6:e1001072-e1001072, 2010; PubMed: 20865120; DOI: 10.1371/journal.ppat.1001072

Experimental method

X-RAY DIFFRACTION (2.6 Å)