3NGL

Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum

Summary for 3NGL

• Entry DOI: 10.2210/pdb3ngl/pdb
• Related: 3NGX
• Descriptor: Bifunctional protein folD, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• Functional Keywords: methylenetetrahydrofolate dehydrogenase/cyclohydrolase, catalyzes the oxidation of 5, 10-methylenetetrahydrofolate to 5, 10-methenyltetrahydrofolate, the hydrolysis of 5, 10-methenyltetrahydrofolate to 10-formyltetrahydrofolate, oxidoreductase, hydrolase
• Biological source: Thermoplasma acidophilum
• Total number of polymer chains: 2
• Total formula weight: 62805.37

Authors

Sung, M.W.,Lee, W.H.,Hwang, K.Y. (deposition date: 2010-06-12, release date: 2011-04-20, Last modification date: 2024-03-20)

• Primary citation: Lee, W.H.,Sung, M.W.,Kim, J.H.,Kim, Y.K.,Han, A.,Hwang, K.Y.; Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum; Biochem.Biophys.Res.Commun., 406:459-463, 2011; PubMed: 21333632; DOI: 10.1016/j.bbrc.2011.02.074

Experimental method

X-RAY DIFFRACTION (2.4 Å)