3NGL

Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
A	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
A	0005829	cellular_component	cytosol
A	0035999	biological_process	tetrahydrofolate interconversion
C	0003824	molecular_function	catalytic activity
C	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
C	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
C	0005829	cellular_component	cytosol
C	0035999	biological_process	tetrahydrofolate interconversion

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE NAP A 305

Chain	Residue
A	THR135
A	VAL201
A	GLY202
A	PHE206
A	VAL221
A	GLY222
A	ILE223
A	VAL253
A	THR257
A	HOH280
A	ASN157
A	ARG158
A	SER159
A	VAL161
A	HIS181
A	SER182
A	ILE187
A	ALA200

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site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAP C 305

Chain	Residue
C	THR135
C	ASN157
C	ARG158
C	SER159
C	VAL161
C	VAL162
C	HIS181
C	SER182
C	ILE187
C	ALA200
C	VAL201
C	GLY202
C	ARG203
C	PHE206
C	VAL221
C	ILE223
C	VAL253
C	THR257
C	HOH290
C	HOH294
C	HOH298

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Functional Information from PROSITE/UniProt

site_id	PS00767
Number of Residues	9
Details	THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPITA

Chain	Residue	Details
A	PRO250-ALA258

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01576","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21333632","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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