3NGL

Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0003824	molecular_function	catalytic activity
A	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
A	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016787	molecular_function	hydrolase activity
A	0035999	biological_process	tetrahydrofolate interconversion
C	0000105	biological_process	L-histidine biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0004477	molecular_function	methenyltetrahydrofolate cyclohydrolase activity
C	0004488	molecular_function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016787	molecular_function	hydrolase activity
C	0035999	biological_process	tetrahydrofolate interconversion

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE NAP A 305

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAP C 305

Functional Information from PROSITE/UniProt

site_id	PS00767
Number of Residues	9
Details	THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPITA

Chain	Residue	Details
A	PRO250-ALA258

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01576, ECO:0000269\|PubMed:21333632