3NF9

Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design

Summary for 3NF9

Entry DOI	10.2210/pdb3nf9/pdb
Related	1bhl 1bi4 1biu 1ex4 1k6y 3NF6 3NF7 3NF8 3NFA
Descriptor	Integrase, SULFATE ION, 5-[(6-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-1,3-benzodioxole-4-carboxylic acid, ... (6 entities in total)
Functional Keywords	integrase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	42321.95
Authors	Peat, T.S.,Newman, J.,Deadman, J.J.,Rhodes, D. (deposition date: 2010-06-10, release date: 2011-04-27, Last modification date: 2024-03-20)
Primary citation	Rhodes, D.I.,Peat, T.S.,Vandegraaff, N.,Jeevarajah, D.,Le, G.,Jones, E.D.,Smith, J.A.,Coates, J.A.,Winfield, L.J.,Thienthong, N.,Newman, J.,Lucent, D.,Ryan, J.H.,Savage, G.P.,Francis, C.L.,Deadman, J.J. Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design ANTIVIR.CHEM.CHEMOTHER., 21:155-168, 2011 Cited by PubMed: 21602613 DOI: 10.3851/IMP1716 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation