3NAX

PDK1 in complex with inhibitor MP7

3NAX の概要

• エントリーDOI: 10.2210/pdb3nax/pdb
• 関連するPDBエントリー: 3NAY
• 分子名称: 3-phosphoinositide-dependent protein kinase 1, 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: kinase, serine/threonine protein kinase, transferase
• 由来する生物種: Homo sapiens
• 細胞内の位置: Cytoplasm: O15530
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36610.96

構造登録者

Yan, Y.,Munshi, S.K.,Allison, T. (登録日: 2010-06-02, 公開日: 2010-11-24, 最終更新日: 2024-02-21)

• 主引用文献: Nagashima, K.,Shumway, S.D.,Sathyanarayanan, S.,Chen, A.H.,Dolinski, B.,Xu, Y.,Keilhack, H.,Nguyen, T.,Wiznerowicz, M.,Li, L.,Lutterbach, B.A.,Chi, A.,Paweletz, C.,Allison, T.,Yan, Y.,Munshi, S.K.,Klippel, A.,Kraus, M.,Bobkova, E.V.,Deshmukh, S.,Xu, Z.,Mueller, U.,Szewczak, A.A.,Pan, B.S.,Richon, V.,Pollock, R.,Blume-Jensen, P.,Northrup, A.,Andersen, J.N.; Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.; J.Biol.Chem., 286:6433-6448, 2011; PubMed: 21118801; DOI: 10.1074/jbc.M110.156463

実験手法

X-RAY DIFFRACTION (1.75 Å)