Structure of neuronal nitric oxide synthase heme domain in complex with 4-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenethyl)-6-methylpyridin-2-amine

Summary for 3N5V

Related3N5P 3N5Q 3N5R 3N5S 3N5T 3N5W 3N5X 3N5Y 3N5Z 3N60 3N61 3N62 3N63 3N64 3N65 3N66 3N67 3N68 3N69 3N6A 3N6B 3N6C 3N6D 3N6E 3N6F 3N6G
DescriptorNitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsheme enzyme, nitric oxide synthase, substrate inhibitor, zn binding', oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceRattus norvegicus (rat)
Total number of polymer chains2
Total molecular weight100216.96
Li, H.,Delker, S.L.,Poulos, T.L. (deposition date: 2010-05-25, release date: 2011-02-09, Last modification date: 2019-07-17)
Primary citation
Delker, S.L.,Xue, F.,Li, H.,Jamal, J.,Silverman, R.B.,Poulos, T.L.
Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49:10803-10810, 2010
PubMed: 21138269 (PDB entries with the same primary citation)
DOI: 10.1021/bi1013479
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24550 3.4% 6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28