3N66
Structure of neuronal nitric oxide synthase S602H mutant heme domain in complex with 6,6'-(2,2'-(5-amino-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)
Summary for 3N66
Entry DOI | 10.2210/pdb3n66/pdb |
Related | 3N5P 3N5Q 3N5R 3N5S 3N5T 3N5V 3N5W 3N5X 3N5Y 3N5Z 3N60 3N61 3N62 3N63 3N64 3N65 3N67 3N68 3N69 3N6A 3N6B 3N6C 3N6D 3N6E 3N6F 3N6G |
Descriptor | Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-[(5-aminobenzene-1,3-diyl)diethane-2,1-diyl]bis(4-methylpyridin-2-amine), ... (8 entities in total) |
Functional Keywords | heme enzyme, nitric oxide synthase, substrate inhibitor, zn binding', oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Rattus norvegicus (rat) |
Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100321.43 |
Authors | Li, H.,Delker, S.L.,Poulos, T.L. (deposition date: 2010-05-25, release date: 2011-02-09, Last modification date: 2023-09-06) |
Primary citation | Delker, S.L.,Xue, F.,Li, H.,Jamal, J.,Silverman, R.B.,Poulos, T.L. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase . Biochemistry, 49:10803-10810, 2010 Cited by PubMed: 21138269DOI: 10.1021/bi1013479 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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