3N5G
Crystal Structure of histidine-tagged human thymidylate synthase
Summary for 3N5G
Entry DOI | 10.2210/pdb3n5g/pdb |
Related | 3N5E |
Descriptor | Thymidylate synthase, SULFATE ION (3 entities in total) |
Functional Keywords | peptide inhibitor, protein-peptide complex, interface inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P04818 |
Total number of polymer chains | 1 |
Total formula weight | 37671.04 |
Authors | Pozzi, C.,Cardinale, D.,Guaitoli, G.,Tondi, D.,Luciani, R.,Myllykallio, H.,Ferrari, S.,Costi, M.P.,Mangani, S. (deposition date: 2010-05-25, release date: 2011-06-08, Last modification date: 2023-09-06) |
Primary citation | Cardinale, D.,Guaitoli, G.,Tondi, D.,Luciani, R.,Henrich, S.,Salo-Ahen, O.M.,Ferrari, S.,Marverti, G.,Guerrieri, D.,Ligabue, A.,Frassineti, C.,Pozzi, C.,Mangani, S.,Fessas, D.,Guerrini, R.,Ponterini, G.,Wade, R.C.,Costi, M.P. Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. Proc.Natl.Acad.Sci.USA, 108:E542-E549, 2011 Cited by PubMed: 21795601DOI: 10.1073/pnas.1104829108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
Download full validation report