3N50

Human Early B-cell factor 3 (EBF3) IPT/TIG and HLHLH domains

Summary for 3N50

Entry DOI	10.2210/pdb3n50/pdb
Related	3MUJ
Descriptor	Transcription factor COE3 (1 entity in total)
Functional Keywords	beta-barrel, helix-loop-helix-loop-helix, structural genomics consortium, sgc, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Potential): Q9H4W6
Total number of polymer chains	6
Total formula weight	105295.49
Authors	Lehtio, L.,Siponen, M.I.,Arrowsmith, C.H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Schuler, H.,Schutz, P.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Wahlberg, E.,Weigelt, J.,Welin, M.,Wisniewska, M.,Berglund, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-05-24, release date: 2010-06-16, Last modification date: 2023-09-06)
Primary citation	Siponen, M.I.,Wisniewska, M.,Lehtio, L.,Johansson, I.,Svensson, L.,Raszewski, G.,Nilsson, L.,Sigvardsson, M.,Berglund, H. Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif. J.Biol.Chem., 285:25875-25879, 2010 Cited by PubMed: 20592035 DOI: 10.1074/jbc.C110.150482 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.102 Å)

Structure validation