3N3J

Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor

Summary for 3N3J

• Entry DOI: 10.2210/pdb3n3j/pdb
• Related: 3MZC 3N0N 3N2P 3N4B
• Descriptor: Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: lyase, metalloenzyme, zinc ligands, benzenesulfonamide, inhibitor, glycerol, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens
• Cellular location: Cytoplasm : P00918
• Total number of polymer chains: 1
• Total formula weight: 29779.97

Authors

Avvaru, B.S.,Wagner, J.,Robbins, A.H.,McKenna, R. (deposition date: 2010-05-20, release date: 2011-03-09, Last modification date: 2023-09-06)

• Primary citation: Pacchiano, F.,Aggarwal, M.,Avvaru, B.S.,Robbins, A.H.,Scozzafava, A.,McKenna, R.,Supuran, C.T.; Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.; Chem.Commun.(Camb.), 46:8371-8373, 2010; PubMed: 20922253; DOI: 10.1039/c0cc02707c

Experimental method

X-RAY DIFFRACTION (1.5 Å)